Avian Pox

Other names: Bird Pox, Fowl Pox, Avian Diphtheria


Avian pox is an infectious disease of birds caused by a poxvirus. There are many different species and strains of avian poxvirus that preferentially infect different species of birds. This is one of the oldest known avian diseases. 


While avian pox infections in wild birds are often mild and self-limiting, some outbreaks cause high mortality rates. Birds native to isolated islands are particularly susceptible to this disease. In Hawaii, avian pox has negatively impacted many species of native birds. Avian pox can lead to significant losses when many captive birds are housed in close quarters. The virus can also spread between wild and captive birds (see Transmission). 

Species Affected

Most bird species are believed to be susceptible to avian pox. About 230 species of wild and domestic birds have been reported with this disease; turkeys, finches, and doves are the most commonly affected wild bird species in New England. Upland game birds (such as mourning doves and wild turkeys), songbirds, and raptors can experience varying degrees of mortality due to avian pox. Wild waterfowl in North America have recently experienced an apparent increase in infection rate, though infections in these birds are still relatively uncommon. Domestic birds can also become infected with this disease, but wild birds are not thought to be a major source of infection for domestic birds. Avian poxviruses are not known to infect humans. 


Avian pox is distributed worldwide except Antarctica, the Arctic, and some other remote regions. Infection rates appear to be greater in areas with temperate and warmer climates. The virus has been introduced to several remote islands such as Hawaii, the Galapagos, and the Canary Islands where it spreads rapidly among the native bird populations. Poxvirus outbreaks are common in aviaries, rehabilitation centers, and whenever captive birds are housed closely together. 


Biting insects such as mosquitoes, mites, fleas, midges, and flies are most frequently responsible for transmitting avian pox. These insects pick up virus particles when they bite an infected bird then transmit the virus when they bite another susceptible bird. Transmission rates are highest when biting insects are abundant. The virus can also be acquired via direct contact with infected birds or contact with contaminated objects such as bird feeders. Avian poxvirus can withstand drying and can remain infectious on contaminated surfaces and in dust. The virus particles can become aerosolized and infect susceptible birds via inhalation, though this is rare. Birds can become infected by ingesting contaminated food or water. The virus can also enter the body through skin abrasions. Transmission rates are influenced by bird population density, and higher infection rates occur when bird densities are greatest. 

Clinical Signs

Avian pox develops slowly in affected birds. The most common clinical sign of avian pox is the formation of wart-like growths on the skin, particularly on unfeathered parts of the body such as the legs, feet, eyelids, base of the beak, and the comb and wattles. This is the cutaneous or “dry” form of avian pox. Birds with mild infections may only have a few growths that minimally affect their health status. In most cases, the bird will survive and the nodules will heal with some scarring. At times, nodules on the eyes can interfere with the bird’s ability to see food or predators and can lead to death. In more severe cases, birds may develop necrotic, yellow-white, cheese-like lesions in their mouths and upper respiratory tract (this is known as the diphtheritic or “wet” form of the disease) which can lead to decreased food intake, difficulty breathing, and death. 


Other diseases can have clinical signs similar to avian pox, so laboratory tests must be conducted to confirm the diagnosis. It is a common mistake to confuse avian pox with blackhead, a protozoal disease that causes the intestines to become inflamed and ulcerated. The name blackhead can be misleading, as this disease rarely results in discoloration of the head. A more specific sign of blackhead is the presence of yellow rings on the liver. 


Captive birds may be treated by sterilizing the lesions and bathing the affected areas with diluted iodine. It is not recommended to try to remove these lesions. Broad-spectrum antibiotics may be given to prevent secondary bacterial infections. These methods will not eliminate the virus, and the disease will run its course with or without treatment. No treatment is available for free-ranging species.


The main goal of avian pox control efforts is to prevent further disease transmission. Mosquito control and elimination of breeding sites is an important aspect of poxvirus transmission prevention. Severely infected birds should also be removed. Avian pox is often transmitted when birds congregate at bird feeders. When outbreaks occur, bird feeders, baths, and cages should be decontaminated with a 10% bleach and water solution (9 parts water:1 part bleach). The domestic poultry industry vaccinates against avian pox, but the safety and effectiveness of such vaccines in wild birds is currently unknown. 

Suggested Reading


Wild turkey with avian poxWild turkey with avian pox; photo courtesy of PSU Animal Diagnostic Lab