Lyme Disease

This fact sheet was update on 12/9/20.

Other names: Lyme borreliosis, Erythema migrans


Lyme disease is a tick-borne disease of humans and certain domestic mammals caused by the bacteria Borrelia burgdorferi and rarely, Borrelia mayonii. Wild mammals, birds and possibly some reptiles are often asymptomatic reservoirs for the bacteria and rarely become ill. The first case of Lyme disease in the United States was described in 1969 in a Wisconsin grouse hunter. The disease received its name after an outbreak occurred in 1975 in children from Lyme, Connecticut, though the bacteria responsible for causing the disease was not identified until 1982. 


Lyme disease can cause mild to severe illness in humans. It is common in the Northeastern United States, particularly in areas where the Ixodes ticks (black-legged or deer ticks) are abundant. If left untreated, the illness can progress to serious conditions involving the joints, heart, and nervous system. Lyme disease is currently the most commonly reported vector-borne disease in humans in the United States, affecting as many as 300,000 people every year. 

Species Affected

Along with humans, B. burgdorferi has been isolated in many species of wild mammals, birds and some reptiles. In North America, the bacteria have been found in coyotes, raccoons, chipmunks, rabbits, and several species of rats, mice, and shrews. The bacteria have also been isolated in several bird species including but not limited to the mallard, ring-necked pheasant, wild turkey, house wren, song thrush, American robin, gray catbird, song sparrow, and house sparrow, without causing disease. B. burgdorferi has been isolated in skinks, green anoles and several species of lizard. Domestic animals including dogs, cats, cattle, and horses can also become infected.


Lyme disease is regularly reported in Japan, China, Western Europe, countries of the former Soviet Union, the United States, southern Canada, and Australia. Cases are occasionally reported in Africa and South America. In the United States, most cases occur in the northeast and mid-Atlantic region, but it has been reported in every state except for Hawaii. In 2018, 94% of reported cases of Lyme disease in the US occurred in the following 15 states: Maine, Vermont, New Hampshire, Rhode Island, Connecticut, New York, New Jersey, Pennsylvania, Maryland, Delaware, West Virginia, Virginia, Ohio, Wisconsin and Minnesota.


The black-legged tick (Ixodes scapularis), also known as the deer tick, is the most important vector for B. burgdorferi in the Eastern and Midwestern United States. Black-legged ticks are sometimes be referred to as “three-host” ticks because they feed on blood from different vertebrate hosts at each of the three different life cycle stages. The western black-legged tick (Ixodes pacificus) is the primary vector in the western US. Other tick species and biting insects such as mosquitoes, deer flies, and horse flies can also carry the bacteria, but it is still unclear how effectively they can transmit it to a new host. 

The tick life cycle plays an important role in the transmission of Lyme disease. After hatching from the egg, the tick progresses through three different stages; larva, nymph and adult. At each stage, the tick obtains a blood meal from a host, drops to the ground, molts its skin and develops to the next stage.

When the larvae hatch in the spring, they do not carry the B. burgdorferi bacteria. During the summer, the larvae feed on the blood of mice, squirrels, raccoons, rabbits, and other small vertebrates. The larvae mature into nymphs in the fall and hibernate over the winter. The larval and nymphal ticks can become carriers of the Lyme bacteria by feeding on wildlife reservoir hosts. White-footed mice (Peromyscus leucopus) and eastern chipmunks (Tamias striatus) are the most important reservoirs for B. burgdorferi in the Eastern and Midwestern United States. If they acquired the bacteria as larvae, the nymphs can transmit the bacteria to new vertebrate hosts when they feed the following spring or summer. They can also acquire the bacteria as nymphs and infect other species in the fall of that year. Therefore the bacteria are most commonly transmitted to humans by nymphs. In the fall, the nymphs develop into adults that feed on their third and final host. Adults previously infected as larvae or nymphs can also transmit the bacteria to new hosts, including humans and domestic animals. Adult female black-legged ticks feed preferentially on deer to gain energy to lay eggs, but deer do not act as reservoirs for the Lyme bacteria. Females lay eggs the following spring then both male and female adults die, and the cycle continues. 

Clinical Signs

Most wild mammals and birds do not appear to show clinical signs of Lyme disease with the exception of the white-footed mouse. White-footed mice may temporarily exhibit reddening of the ears and neurological signs including trembling, head tilt, circling to one side, loss of coordination, and weakness of the hind limbs. Some domestic animals, especially dogs, develop clinical signs including fever, stiffness, lameness, and arthritis. Less commonly, domestic animals may experience kidney, neurologic, eye, and cardiac problems. Humans with Lyme disease often (85% of the time) develop a “bull’s eye lesion” (known as erythema migrans) at the location of tick attachment followed by fever, fatigue, and headache. If left untreated, humans can experience more serious conditions involving the joints, heart, and nervous system. Human infections usually occur between May and September which coincides with tick abundance.


Lyme disease is diagnosed using laboratory tests.


Humans and domestic animals can be treated successfully with antibiotics, especially when the infection is addressed early. Wildlife species do not develop Lyme disease, so treatment is not considered.


People should take certain precautions to reduce the risk of contracting Lyme disease. When spending time outdoors in potential tick habitats, long pants tucked into socks or boots, and insect repellent are recommended. Each day spent in tick habitat should be followed by a thorough “tick check”. Ticks found on people or pets should be removed promptly and completely. Veterinarian recommended tick control products should be used on pets that spend time outdoors. Lyme disease vaccines are no longer available for humans, but vaccines are available for pets.

Suggested Reading


Reported cases of Lyme Disease, U.S., 2012.Reported cases of Lyme Disease in the United States in 2012. Map courtesy of
Life cycle of Black-legged tickLife cycle of Black-legged tick, Courtesy of
Life stages of Black-legged tick.Life stages of Black-legged tick.